Unlocking 10x Performance with NVIDIA B200 GPUs on AWS ParallelCluster
The NVIDIA B200 GPU represents a quantum leap in AI/ML compute performance. Learn how
our team integrates B200 instances with AWS ParallelCluster and Slurm scheduling to
deliver unprecedented performance for large language models and genomics workloads.
We explore architectural patterns for optimal GPU utilization, network topology design
with EFA, and cost optimization strategies that achieved 3x cost reduction for our biotech clients.
NVIDIA B200
AWS ParallelCluster
GPU Optimization
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Building Enterprise HPC Platforms: Slurm Workload Manager Best Practices
Slurm has become the de facto standard for HPC workload orchestration, but configuring
it for cloud environments requires specialized expertise. This deep-dive covers our
battle-tested approaches to Slurm configuration on AWS ParallelCluster, including
multi-queue architectures, job accounting, fair-share scheduling, and integration with
Weka parallel file systems for high-throughput data access supporting 200+ researchers.
Slurm
HPC Platform
AWS ParallelCluster
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Weka Data Platform: High-Performance Storage for AI/HPC Workloads
Traditional storage systems become bottlenecks for modern AI/HPC platforms. Discover
how we leverage Weka's parallel file system to deliver multi-GB/s throughput for
GPU-accelerated workloads on AWS. Learn about our reference architecture combining
Weka with AWS ParallelCluster, achieving sub-millisecond latency and seamless scaling
from terabytes to petabytes—critical for genomics data pipelines and large-scale ML training.
Weka
Storage Architecture
Performance
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AWS ParallelCluster 3.0: Building Modern HPC Platforms with Infrastructure-as-Code
AWS ParallelCluster 3.0 brings revolutionary improvements for cloud HPC deployments.
We share our production-tested Terraform patterns for deploying multi-region HPC platforms
with Slurm scheduler, NVIDIA B200 GPU nodes, and Weka storage integration. Topics include
automated cluster lifecycle management, cost optimization with spot instances, and security
best practices for Trusted Research Environments handling sensitive genomics data.
AWS ParallelCluster
Terraform
DevSecOps
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